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Har Gobind Khorana was an Indian-American molecular biologist of Indian-Punjabi origin. Har Gobind Khorana, the Indian born biochemist, was responsible for producing the first man made gene in his laboratory. For demonstrating how the nucleotides in nucleic acids control the cell's synthesis of proteins, Khorana was awarded the Nobel Prize in Medicine in 1968, sharing the honor with Robert W. Holley and Marshall W. Nirenberg. Khorana was also the first to synthesize strings of nucleotides, called oligonucleotides; the first to isolate deoxyribonucleic acid (DNA) ligase (the enzyme that connects pieces of DNA); and the first to synthesize an artificial yeast gene. He devised an improved method for synthesizing acetyl coenzyme A, and ascertained the sequence of DNA nucleotide triplets. Khorana's work is an important scientific landmark of the 20th Century.