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There are several blood group systems present on the red blood cell membrane. The ABO blood group system is the most important in human transfusion. Within the ABO blood group system, an individual can be typed as A, B, AB or O depending on the nature of the protein (called antigen) present on his red blood cells, and the nature of the antibody present in his plasma. In terms of blood transfusions, the rule is to give the same blood type or a blood type lacking the antigen against which the individual has the corresponding antibody in the plasma. Therefore, type A individuals can receive blood from type A or type O individuals; type B can receive blood from type B or type O individuals; type AB can receive blood from type AB, type A, type B or type O individuals; and type O can receive blood only from type O individuals. Since any blood type in the ABO system can receive blood from type O individuals; type O is called the universal blood type.