Myxoedema is due to

Options :
  1. excess of gonadotropic hormone
  2. excess thyroxine
  3. decreases insulin
  4. decreased thyroxine
Answer and Explanation :-

Answer: Option 4

Explanation:

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She had stayed home and worked hard and a posthumous recognition had eventually followed. Not that Buck hadn't worked hard, sure he did, but in the end the body won't hold up as a work of art.
-Duff Brenna The Altar of the Body: A Novel