Lesch-Nyhan Syndrome is caused due to the deficiency of.....

Options :
  1. Hypoxanthine guanine phosphoribosyl transferase
  2. Isocitrate dehydrogenase
  3. Xanthine oxidoreductase
  4. adenine phosphoribosyltransferase

Answer and Explanation :-

Answer: Option 1


HGPRT is a transferase that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate. HGPRT plays a central role in the generation of purine nucleotides through the purine salvage pathway. Lesch-Nyhan syndrome is due to HPRT mutations resulting in extremely ineffective enzyme activity.

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